The chicken chorioallantoic membrane tumor assay as model for qualitative testing of oncolytic adenoviruses
نویسندگان
چکیده
منابع مشابه
The chick chorioallantoic membrane as a novel in vivo model for the testing of biomaterials.
Current in vivo models for testing biomaterials are time and labor intensive as well as expensive. This article describes a new approach for testing biomaterials in vivo using the chorioallantoic membrane (CAM) of the developing chicken embryo, as an alternative to the traditional mammalian models. Fertilized chicken eggs were incubated for 4 days, at which time a small window was cut in the sh...
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متن کاملOncolytic adenoviruses
The therapeutic efficacy of oncolytic viruses including adenovirus has been thought to depend mostly on direct viral destruction of tumor cells. However, this view has changed with the discovery that oncolysis can also induce innate and antigen-specific adaptive immunity against the tumor. Here we summarize our findings from cancer patients.
متن کاملThe chick embryo chorioallantoic membrane as a model for tumor biology.
Among the in vivo models, the chick embryo chorioallantoic membrane (CAM) has been used to implant several tumor types as well as malignant cell lines to study their growth rate, angiogenic potential and metastatic capability. This review article is focused on the major compelling literature data on the use of the CAM to investigate tumor growth and the metastatic process.
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ژورنال
عنوان ژورنال: Cancer Gene Therapy
سال: 2011
ISSN: 0929-1903,1476-5500
DOI: 10.1038/cgt.2011.68